October 3, 1997
In what year was the first mouse successfully cloned?
The first mouse from adult cells, Cumulina, was born in 1997 at the University of Hawai’i at Mānoa in the laboratory of Ryuzo Yanagimachi using the Honolulu technique. In 2008 Japanese scientists created a cloned mouse from a dead mouse that had been frozen for 16 years.
Why was Cumulina the mouse cloned?
The donor nucleus came from cumulus cells, which surround the developing eggs in the ovaries of female mice. Cumulina raised two litters before “retiring.” About eight months ago, Cumulina developed a skin tumor, common in aging mice, and the tumor was removed.
How was Mira the goat cloned?
Mira and her sisters were made using a variation on the nuclear transfer technique that produced Dolly the Sheep, the first mammal cloned from an adult cell. In this case, the researchers took genetic material from a 40-day-old goat embryo which carried the transgene that expressed rhAT III.
What has been cloned?
Two years later, researchers in Japan cloned eight calves from a single cow, but only four survived. Besides cattle and sheep, other mammals that have been cloned from somatic cells include: cat, deer, dog, horse, mule, ox, rabbit and rat. In addition, a rhesus monkey has been cloned by embryo splitting.